PLA2G4A and RPS6KA5

Data Source:
HPRD (in vitro)

		PLA2G4A	RPS6KA5
Description		phospholipase A2 group IVA	ribosomal protein S6 kinase A5
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Phosphatidylinositol-4-phosphate Binding Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine) Ceramide 1-phosphate Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Monoacylglycerol Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Positive Regulation Of Platelet Activation Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Glycerophospholipid Catabolic Process Arachidonic Acid Secretion Cellular Response To Antibiotic	Negative Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways		phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonic acid metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs		Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)	Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AW H2BC21 H2BC3 H2BU1 H3-4 H3C14 H3C6 H4-16 H4C14 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		5321	9252
HPRD ID		08986	06789
Ensembl ID		ENSG00000116711	ENSG00000100784
Uniprot IDs		B4DZI4 P47712	O75582
PDB IDs		1BCI 1CJY 1RLW	1VZO 3KN5 3KN6
Enriched GO Terms of Interacting Partners?
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