PKLR and CLEC4G

Data Source:
BioGRID (two hybrid)

		PKLR	CLEC4G
Description		pyruvate kinase L/R	C-type lectin domain family 4 member G
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Potassium Ion Binding	Virus Receptor Activity Protein Binding Mannose Binding Polysaccharide Binding Fructose Binding Carbohydrate Derivative Binding Glycosylated Region Protein Binding
	Biological Process	Response To Hypoxia Glycolytic Process ATP Biosynthetic Process Response To Nutrient Response To Heat Response To Glucose Response To Lithium Ion Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Response To CAMP Canonical Glycolysis Cellular Response To Epinephrine Stimulus	Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of T Cell Proliferation Viral Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Viral Life Cycle
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Pyruvic acid 2-Phosphoglycolic Acid beta-D-fructofuranose 1,6-bisphosphate
Diseases		Pyruvate kinase (PK) deficiency, including: Red cell pyruvate kinase (PK) deficiency; Pyruvate kinase hyperactivity
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 24777453) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Major depressive disorder ( 29317602) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 23263486)	Blood protein levels ( 28240269) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		4 interacting genes: CLEC4G CPNE7 MYOC PCNA	26 interacting genes: APOA1 APOH ARL13B ARSA ASGR1 AZU1 CAPN1 CPLX4 CPN1 EBAG9 EIF6 FAM209A FTL GEM IFI35 LRRC4C MAP3K11 MT-CO1 NUP214 PKLR PRDX1 PTPN5 RPSA SHBG SIGLEC12 WBP2
Entrez ID		5313	339390
HPRD ID		11841	16721
Ensembl ID		ENSG00000143627	ENSG00000182566
Uniprot IDs		P30613	B7ZKQ2 Q08G24 Q6UXB4 Q6XYD1
PDB IDs		2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 6NN4 6NN5 6NN7 6NN8
Enriched GO Terms of Interacting Partners?
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