PHB and LONRF3

Data Source:
BioGRID (pull down)

		PHB	LONRF3
Description		prohibitin	LON peptidase N-terminal domain and ring finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Mitochondrial Crista Extrinsic Component Of Mitochondrial Outer Membrane Mitochondrial Prohibitin Complex Extracellular Exosome Extrinsic Component Of Presynaptic Active Zone Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity	Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Ovarian Follicle Atresia Osteoblast Differentiation Immunoglobulin Production Regulation Of Transcription, DNA-templated Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Signal Transduction Activation Of Phospholipase C Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation CD40 Signaling Pathway Negative Regulation Of Cell Growth Animal Organ Regeneration Interleukin-17 Production Response To Immobilization Stress RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Protein Catabolic Process Response To Drug Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Peptide Hormone Modulation By Host Of Viral RNA Genome Replication Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Viral Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants
Drugs		Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Asthma ( 31959851 30929738 32296059 29273806) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Cancer ( 29299148) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 19430483 27841878) Lower body strength ( 27325353) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Restricted and repetitive behaviours in autism spectrum disorder ( 28533516) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		25 interacting genes: ANXA2 BCAS3 CASC3 CCL5 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1	9 interacting genes: APPBP2 CTAG1A CTAG1B CYSRT1 DES ENO1 NOTCH2NLA PHB SMURF1
Entrez ID		5245	79836
HPRD ID		01454	06708
Ensembl ID		ENSG00000167085	ENSG00000175556
Uniprot IDs		A8K401 P35232 Q53FV0	A8K2D3 B3KUN7 Q496Y0
PDB IDs		1LU7
Enriched GO Terms of Interacting Partners?
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