PFN1 and CMA1

Data Source:
HPRD (in vitro)

		PFN1	CMA1
Description		profilin 1	chymase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytosol Secretory Granule Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Proline-rich Region Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding
	Biological Process	Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Ruffle Assembly	Angiotensin Maturation Extracellular Matrix Disassembly Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Cytokine Precursor Processing
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins	Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol	Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS		Mean platelet volume ( 32888494)
Interacting Genes		33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		5216	1215
HPRD ID		01452	00346
Ensembl ID		ENSG00000108518	ENSG00000092009
Uniprot IDs		P07737	P23946 Q4FEB3
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW	1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP
Enriched GO Terms of Interacting Partners?
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