CAB39 and SHMT2

Data Source:
BioGRID (two hybrid)

		CAB39	SHMT2
Description		calcium binding protein 39	serine hydroxymethyltransferase 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Membrane Z Disc Secretory Granule Lumen Extracellular Exosome Serine/threonine Protein Kinase Complex Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity	Translation Repressor Activity, MRNA Regulatory Element Binding Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	Cell Cycle Arrest Signal Transduction Positive Regulation Of Peptidyl-threonine Phosphorylation Response To Activity Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Intracellular Signal Transduction Neutrophil Degranulation Cellular Hypotonic Response Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Thyroid Hormone Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration
Pathways		Energy dependent regulation of mTOR by LKB1-AMPK Neutrophil degranulation	Metabolism of folate and pterines
Drugs			Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: CEP44 GOLGA2 IPO5 MCCD1 MED7 PRKAA1 RSL1D1 SHMT2 STK11 STK24 STRADA STRADB	18 interacting genes: ABRAXAS2 APP ARL6IP1 BABAM1 BABAM2 BRCC3 CAB39 CLEC2D CMTM5 CREB3 CSNK2B DUX4 ESR1 FBXO7 KASH5 MAL2 NDRG1 PPARD
Entrez ID		51719	6472
HPRD ID		10091	00717
Ensembl ID		ENSG00000135932	ENSG00000182199
Uniprot IDs		A0A024R496 Q9Y376	A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06
PDB IDs		1UPK 1UPL 2WTK 3GNI 4FZA 4FZD 4FZF 4NZW 4O27	4PVF 5V7I 5X3V 6DK3 6H3C 6QVG 6QVL 6R8F
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?