PDPK1 and KATNBL1

Data Source:
BioGRID (two hybrid)

		PDPK1	KATNBL1
Description		3-phosphoinositide dependent protein kinase 1	katanin regulatory subunit B1 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Perikaryon	Nucleus Nucleoplasm Nucleolus Cytoplasm Midbody Cleavage Furrow Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Insulin Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Protein Kinase Binding Phospholipase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Microtubule Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Type B Pancreatic Cell Development Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Calcium-mediated Signaling Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Focal Adhesion Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Cytoskeleton Organization
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ
Drugs		Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib
Diseases
GWAS
Interacting Genes		60 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK DDIT4 GIT1 HSP90AA1 ILK IRS1 ITGB3 KATNBL1 LUC7L2 MAPK8 MTOR PAK1 PEA15 PHAX PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SLC9A3R2 SMARCB1 SOCS3 SRC SRPK1 STRAP TCAP WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133	39 interacting genes: CA12 CDC37 CLIC3 CPNE2 FRS3 GEM GPANK1 GUCD1 GYS1 HAP1 KAT7 KATNAL1 LMO4 LONRF1 MFAP1 MYO15B NEK6 NTAQ1 NXF1 OSGIN1 PDPK1 PFKFB1 PIBF1 POLR3C PRKAB2 PSMB1 RAD51D SCNM1 SDCBP SMARCD1 SNAPC3 TCEANC TRIM41 TUT1 ZC2HC1C ZNF329 ZNF417 ZNF572 ZNF587
Entrez ID		5170	79768
HPRD ID		05556	07995
Ensembl ID		ENSG00000140992	ENSG00000134152
Uniprot IDs		O15530	A0A024R9P5 Q9H079
PDB IDs		1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD
Enriched GO Terms of Interacting Partners?
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