ATP5MC2 and TDP2

Data Source:
BioGRID (two hybrid)

		ATP5MC2	TDP2
Description		ATP synthase membrane subunit c locus 2	tyrosyl-DNA phosphodiesterase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Proton-transporting ATP Synthase Complex, Coupling Factor F(o) Mitochondrial Outer Membrane Integral Component Of Membrane Proton-transporting ATP Synthase Complex, Coupling Factor F(o)	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	Protein Binding Lipid Binding	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS			Colorectal or endometrial cancer ( 26621817)
Interacting Genes		4 interacting genes: ATP13A2 CYSLTR2 TDP2 XRN1	35 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2
Entrez ID		517	51567
HPRD ID		04429	05771
Ensembl ID		ENSG00000135390	ENSG00000111802
Uniprot IDs		Q06055	A0A384MDM5 O95551
PDB IDs			5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?
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