UFM1 and UBA5

Data Source:
BioGRID (enzymatic study)

		UFM1	UBA5
Description		ubiquitin fold modifier 1	ubiquitin like modifier activating enzyme 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding ATP Binding Zinc Ion Binding Protein Homodimerization Activity UFM1 Activating Enzyme Activity
	Biological Process	Brain Development Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation	Protein Phosphopantetheinylation Erythrocyte Differentiation Megakaryocyte Differentiation Protein Modification By Small Protein Conjugation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Neuromuscular Process Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Low vWF levels ( 26486471) Schizophrenia ( 30285260)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: ARHGDIA ARHGDIB DIABLO GSK3B INCA1 KCTD21 RPS6KA6 TSC22D2 UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W	7 interacting genes: APEH GABARAPL2 PKD1P1 UBE2D2 UBE2L3 UFC1 UFM1
Entrez ID		51569	79876
HPRD ID		15644	15598
Ensembl ID		ENSG00000120686	ENSG00000081307
Uniprot IDs		P61960	Q9GZZ9
PDB IDs		1WXS 5HKH 5IA7 5IA8 5IAA 5L95 6H77	3GUC 3H8V 5HKH 5IA8 5IAA 5L95 6H77 6H78 6H8C
Enriched GO Terms of Interacting Partners?
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