RAB6B and RAP1GDS1

Data Source:
BioGRID (two hybrid)

		RAB6B	RAP1GDS1
Description		RAB6B, member RAS oncogene family	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Cytoplasmic Vesicle Presynapse	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin V Binding	GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		14 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 RAP1GDS1 SH2B2 SMAD1 TGFBR1	23 interacting genes: CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS MBIP NRAS PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		51560	5910
HPRD ID		11474	11763
Ensembl ID		ENSG00000154917	ENSG00000138698
Uniprot IDs		Q9NRW1	B3KNU0 P52306 Q6U7G8
PDB IDs		2E9S 2FE4 2FFQ	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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