TBC1D7 and KRT35

Data Source:
BioGRID (two hybrid)

		TBC1D7	KRT35
Description		TBC1 domain family member 7	keratin 35
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle Ciliary Basal Body	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Structural Molecule Activity Protein Binding
	Biological Process	Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly	Anatomical Structure Morphogenesis Keratinization Cornification
Pathways		TBC/RABGAPs	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Migraine ( 23793025) Migraine without aura ( 23793025)
Interacting Genes		30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ	87 interacting genes: ABI3 ATG9A BCAS2 C1orf109 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446
Entrez ID		51256	3886
HPRD ID		18165	04138
Ensembl ID		ENSG00000145979	ENSG00000197079
Uniprot IDs		A0A024QZX0 A0A024R011 Q5JPB9 Q9P0N9 U3KPY5	Q92764
PDB IDs		3QWL 4Z6Y 5EJC 5ULO
Enriched GO Terms of Interacting Partners?
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