TNNI3K and TNNI3

Data Source:
HPRD (in vivo, two hybrid)

		TNNI3K	TNNI3
Description		TNNI3 interacting kinase	troponin I3, cardiac type
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Heart Rate Protein Phosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction Ion homeostasis
Drugs		Fostamatinib	N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26426971 23669352 28892062 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032)	Platelet count ( 32888494)
Interacting Genes		8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3	19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		51086	7137
HPRD ID		18208	11769
Ensembl ID		ENSG00000116783	ENSG00000129991
Uniprot IDs		Q59H18	P19429 Q6FGX2
PDB IDs		4YFF 4YFI 6B5J	1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI
Enriched GO Terms of Interacting Partners?
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