PCM1 and CCDC172

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PCM1	CCDC172
Description		pericentriolar material 1	coiled-coil domain containing 172
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Apical Part Of Cell Non-motile Cilium	Cytoplasm Sperm Midpiece
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Neuron Migration Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Ciliary Basal Body-plasma Membrane Docking Non-motile Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061)
Interacting Genes		43 interacting genes: ABI1 ABI2 AKAP9 BBS4 CASK CCDC172 CCHCR1 CDC42 CEP72 CYTH4 DDIT3 DDX23 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 HAP1 ING5 KLC1 KLC4 KRT15 KRT19 KRT24 MCRS1 NDC80 NECAB2 PCNT PRC1 PRKCI RALBP1 RBM5 RINT1 RPA2 TFIP11 TTC8 WASHC3 YWHAE YWHAQ	21 interacting genes: C2CD6 DCTN2 FAM13C FAM161B HDDC3 ISCU KDM1A MRPL11 MSGN1 NEFL PCDHB12 PCM1 PLEKHF2 PRKAA2 PSTPIP1 SH2D4A SMARCE1 TCHP TEAD4 TXNDC9 VPS9D1
Entrez ID		5108	374355
HPRD ID		02624	18604
Ensembl ID		ENSG00000078674	ENSG00000182645
Uniprot IDs		A2RUU9 B9EIS5 Q15154	P0C7W6
PDB IDs		6HYL 6HYM
Enriched GO Terms of Interacting Partners?
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