TXNDC11 and TPO

Data Source:
HPRD (in vivo)

		TXNDC11	TPO
Description		thioredoxin domain containing 11	thyroid peroxidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Heme Binding
	Biological Process		Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways			Thyroxine biosynthesis
Drugs			Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma renin activity levels ( 29650764) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Triglyceride levels ( 32203549) Weight ( 28552196)	Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 30367059 27182965) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24722205 24586183) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		21 interacting genes: ACAA1 ATXN7 CDKN1A DUOX1 DUOX2 GFI1B HSP90B1 KLHL38 KRT15 KRT18 MKRN3 NOS3 ORC5 RAB2B RACGAP1 RPS19 RPS6KA5 SOCS3 STAT5A TPO ZNF417	2 interacting genes: DUOX1 TXNDC11
Entrez ID		51061	7173
HPRD ID		07125	06000
Ensembl ID		ENSG00000153066	ENSG00000115705
Uniprot IDs		Q6PKC3	P07202 Q502Y3 Q6P534
PDB IDs
Enriched GO Terms of Interacting Partners?
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