ZNF593 and MAP3K7

Data Source:
BioGRID (two hybrid)

		ZNF593	MAP3K7
Description		zinc finger protein 593	mitogen-activated protein kinase kinase kinase 7
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Cytosol Plasma Membrane IkappaB Kinase Complex Endosome Membrane
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Activation Of MAPKK Activity Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Viral Process Positive Regulation Of Macroautophagy Protein Deubiquitination Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways			Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		10 interacting genes: DDIT4L GPR3 LNX1 MAP3K20 MAP3K7 MAPK8IP2 PICK1 POLR1H RAB1A SRPK2	67 interacting genes: AKTIP BBS10 BCL10 CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IKBKG IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TAB3 TGFBR1 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC VRK2 XIAP ZNF593 ZNF746
Entrez ID		51042	6885
HPRD ID		15866	04011
Ensembl ID		ENSG00000142684	ENSG00000135341
Uniprot IDs		O00488	O43318
PDB IDs		1ZR9 6LSS 6LU8	2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N
Enriched GO Terms of Interacting Partners?
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