VPS36 and SNF8

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		VPS36	SNF8
Description		vacuolar protein sorting 36 homolog	SNF8 subunit of ESCRT-II
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Endosome Cytosol Late Endosome Membrane Extracellular Exosome	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding	Protein Binding Protein C-terminus Binding Transcription Factor Binding Channel Regulator Activity Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Regulation Of Multivesicular Body Size Involved In Endosome Transport Endosomal Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Lewy body disease ( 25188341)	Coronary heart disease ( 21378990) Type 2 diabetes ( 29358691)
Interacting Genes		7 interacting genes: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25	24 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA VAC14 VPS25 VPS36 YWHAE
Entrez ID		51028	11267
HPRD ID		12620	16847
Ensembl ID		ENSG00000136100	ENSG00000159210
Uniprot IDs		Q86VN1	Q96H20
PDB IDs		2HTH 2ZME 3CUQ	2ZME 3CUQ
Enriched GO Terms of Interacting Partners?
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