EXOSC1 and NUP160

Data Source:
HPRD (two hybrid)

		EXOSC1	NUP160
Description		exosome component 1	nucleoporin 160
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol	Kinetochore Nuclear Envelope Nuclear Pore Cytosol Nuclear Pore Outer Ring Host Cell
	Molecular Function	RNA Binding Exoribonuclease Activity Protein Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Nephron Development Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Granulocyte percentage of myeloid white cells ( 27863252) Intraocular pressure ( 29617998 25173106 29235454) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Plateletcrit ( 27863252) Pulse pressure ( 30578418) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 30578418)
Interacting Genes		34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76	6 interacting genes: AHCTF1 DISC1 ESRRG EXOSC1 NUP37 SUMO2
Entrez ID		51013	23279
HPRD ID		16223	16254
Ensembl ID		ENSG00000171311	ENSG00000030066
Uniprot IDs		B1AMU3 Q9Y3B2	Q12769
PDB IDs		2NN6 6D6Q 6D6R 6H25	5A9Q
Enriched GO Terms of Interacting Partners?
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