DERL2 and MELTF

Data Source:
HPRD (in vivo)

		DERL2	MELTF
Description		derlin 2	melanotransferrin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Recycling Endosome Extracellular Exosome
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Iron Ion Binding Protein Binding
	Biological Process	Suckling Behavior Positive Regulation Of Cell Population Proliferation Viral Process Positive Regulation Of Cell Growth Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming	Regulation Of Cell Growth Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655)	Malaria ( 31844061)
Interacting Genes		12 interacting genes: DIABLO FXYD6 KRTAP10-3 KRTAP10-7 KRTAP10-8 LMNA MELTF MPP1 PTPN9 RBFA SERPINA1 SFT2D1	10 interacting genes: CYSRT1 DERL1 DERL2 DERL3 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA
Entrez ID		51009	4241
HPRD ID		16796	01122
Ensembl ID		ENSG00000072849	ENSG00000163975
Uniprot IDs		I3L3R8 Q9GZP9	P08582 Q53XS6
PDB IDs
Enriched GO Terms of Interacting Partners?
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