PBX2 and HOXB5

Data Source:
BioGRID (two hybrid)

		PBX2	HOXB5
Description		PBX homeobox 2	homeobox B5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Brain Development Animal Organ Morphogenesis Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Coronary artery disease ( 33020668) Crohn's disease ( 23266558) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Refractive error ( 32231278) Rheumatic heart disease ( 32488134) Ulcerative colitis ( 28067908)	Diverticular disease ( 30177863) Obesity ( 22484627)
Interacting Genes		37 interacting genes: BAIAP2 BFSP2 BLOC1S1 BLOC1S5 BRMS1L CARD9 CCDC88B CDCA7L CENPBD1 COPS6 DCTN3 EFHC1 ELP1 FAM90A1 HOXA1 HOXA5 HOXA9 HOXB5 HOXB8 HOXC5 HOXC8 HOXC9 MCRS1 MSC MTREX NUP62 PBX1 PKNOX1 PPFIBP1 RIPPLY2 RPL4 RPS6KC1 SMYD3 UBE2E1 ZCWPW2 ZDHHC7 ZNF587	62 interacting genes: ASB6 AXIN2 CADPS CALCOCO2 CARD9 CCDC136 CCDC88B CEP70 CNFN CSNK2B CTBP1 CTBP2 CYSRT1 GOLGA2 GOLGA6A GOLGA6L9 HAP1 HOMER3 HOOK2 HSF2BP KIFAP3 KRT31 KRT34 KRTAP1-1 KRTAP10-6 KRTAP10-8 KRTAP6-3 LDOC1 MAGEA11 MEOX2 MID2 MTUS2 NFKBID OIP5 PBX1 PBX2 PBX4 PDE4DIP PHF19 PLXND1 PRDM14 RCHY1 TBC1D26 TEKT4 TEX11 TLE5 TRAF1 TRAF2 TRAF4 TRIB3 TRIM23 TRIM27 TRIM54 USH1G VPS52 ZC4H2 ZMYND12 ZNF286A ZNF552 ZNF655 ZNF774 ZRANB1
Entrez ID		5089	3215
HPRD ID		08890	00848
Ensembl ID		ENSG00000204304	ENSG00000120075
Uniprot IDs		A0A024RCR3 P40425	P09067
PDB IDs
Enriched GO Terms of Interacting Partners?
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