PBX1 and BRMS1L

Data Source:
BioGRID (two hybrid)

		PBX1	BRMS1L
Description		PBX homeobox 1	BRMS1 like transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Sin3-type Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Eye Development Branching Involved In Ureteric Bud Morphogenesis Regulation Of Transcription By RNA Polymerase II Steroid Biosynthetic Process Positive Regulation Of Transcription Of Notch Receptor Target Brain Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Negative Regulation Of Neuron Differentiation Spleen Development Thymus Development Embryonic Organ Development Neuron Development Embryonic Skeletal System Development	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Growth
Pathways		Transcriptional regulation of pluripotent stem cells Activation of anterior HOX genes in hindbrain development during early embryogenesis NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Asthma ( 29273806) Breast cancer (prognosis) ( 23319801) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Early-onset Parkinson's disease ( 28256260) Height ( 20966902) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		31 interacting genes: BRMS1L CDCA7L CREBBP EFHC1 FAM90A1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB5 HOXB7 HOXB8 HOXC5 HOXC8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PIN1 PKNOX1 POU2F1 SMARCD3	22 interacting genes: ACTN2 AMOTL2 BRMS1 CEP70 CYTOR DEUP1 EXOC5 HDAC1 HDAC2 ING1 MCRS1 MID2 PBX1 PBX2 RBBP4 RBBP7 RBP1 SAP30 SIN3A TEX11 TULP3 TXLNA
Entrez ID		5087	84312
HPRD ID		08889	16564
Ensembl ID		ENSG00000185630	ENSG00000100916
Uniprot IDs		A1MJ41 A8K5V0 P40424 Q53YC7	Q5PSV4
PDB IDs		1B72 1PUF
Enriched GO Terms of Interacting Partners?
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