HDGFL3 and IL4R

Data Source:
BioGRID (biochemical)

		HDGFL3	IL4R
Description		HDGF like 3	interleukin 4 receptor
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytosol	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Double-stranded DNA Binding Transcription Coregulator Activity Microtubule Binding Growth Factor Activity Tubulin Binding	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Microtubule Depolymerization Signal Transduction Neuron Projection Development Microtubule Polymerization	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases			Asthma
GWAS			Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		4 interacting genes: H3C1 SMURF1 SMURF2 TERF2IP	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		50810	3566
HPRD ID		17096	00990
Ensembl ID		ENSG00000166503	ENSG00000077238
Uniprot IDs		A0A024R216 Q9Y3E1	B2RBY1 P24394
PDB IDs		6IIP 6IIQ 6IIR 6IIS 6IIT	1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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