PAPPA and ATF7IP

Data Source:
HPRD (two hybrid)

		PAPPA	ATF7IP
Description		pappalysin 1	activating transcription factor 7 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding	Transcription Corepressor Activity Protein Binding ATPase Activity
	Biological Process	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Viral Process Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Stabilization Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PKMTs methylate histone lysines
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Metabolite levels ( 23823483) Pulse pressure ( 30224653)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		10 interacting genes: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	70 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		5069	55729
HPRD ID		01448	09811
Ensembl ID		ENSG00000182752	ENSG00000171681
Uniprot IDs		B4DTA8 Q13219 Q7Z613	A0A024RAY1 B3KNI7 B3KQF8 Q6VMQ6
PDB IDs			2RPQ
Enriched GO Terms of Interacting Partners?
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