GPR143 and SUCLG2

Data Source:
HPRD (in vitro, in vivo)

		GPR143	SUCLG2
Description		G protein-coupled receptor 143	succinate-CoA ligase GDP-forming subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Melanosome Membrane Melanosome	Mitochondrion Mitochondrial Matrix Plasma Membrane Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming)
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Dopamine Binding L-DOPA Receptor Activity L-DOPA Binding Tyrosine Binding	Magnesium Ion Binding Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Eye Pigment Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Visual Perception Melanosome Localization Melanosome Transport Melanosome Organization Calcium-mediated Signaling Using Intracellular Calcium Source Phosphatidylinositol-mediated Signaling Regulation Of Calcium-mediated Signaling	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process
Pathways		Amine ligand-binding receptors G alpha (q) signalling events	Citric acid cycle (TCA cycle)
Drugs			Phenethyl Isothiocyanate
Diseases		Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Congenital motor nystagmus (CMN); Idiopathic congenital nystagmus (ICN)
GWAS		Prostate cancer ( 23535732)	Blood metabolite levels ( 24816252) Body mass index ( 28552196) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320) Corneal astigmatism ( 22144915) Diabetic kidney disease ( 26305897) FEV1 ( 30804560) Height ( 20881960) Hip circumference ( 28552196) IgE levels ( 23146381) Lung function (FVC) ( 28166213 30804560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: GNAI1 SUCLG2	3 interacting genes: GPR143 SGCG SUCLG1
Entrez ID		4935	8801
HPRD ID		02355	06799
Ensembl ID		ENSG00000101850	ENSG00000172340
Uniprot IDs		P51810	Q96I99
PDB IDs			6WCV
Enriched GO Terms of Interacting Partners?
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