DDR2 and COL3A1

Data Source:
HPRD (in vitro)

		DDR2	COL3A1
Description		discoidin domain receptor tyrosine kinase 2	collagen type III alpha 1 chain
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Receptor Complex	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Ossification Endochondral Bone Growth Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Kinase Activity Regulation Of Tissue Remodeling Chondrocyte Proliferation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Extracellular Matrix Disassembly	Skeletal System Development Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Skin Development Regulation Of Immune Response Negative Regulation Of Immune Response Supramolecular Fiber Organization Negative Regulation Of Neuron Migration
Pathways		Non-integrin membrane-ECM interactions	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs		Regorafenib Fostamatinib	Collagenase clostridium histolyticum
Diseases		Spondylometaepiphyseal dysplasia, short limb-hand type; Spondylometaepiphyseal dysplasia, short limb-abnormal calcification type	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Dupuytren's disease ( 28886342) Height ( 31562340)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: COL1A1 COL3A1 SHC1 SRC	14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF
Entrez ID		4921	1281
HPRD ID		01868	00365
Ensembl ID		ENSG00000162733	ENSG00000168542
Uniprot IDs		A0A024R906 Q16832	P02461
PDB IDs		2WUH 2Z4F 6FER	2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW
Enriched GO Terms of Interacting Partners?
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