NOS1 and ARG1

Data Source:
HPRD (in vivo)

		NOS1	ARG1
Description		nitric oxide synthase 1	arginase 1
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Postsynaptic Density Sarcoplasmic Reticulum Protein-containing Complex Sarcolemma Dendritic Spine Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery Ryanodine Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Azurophil Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body
	Molecular Function	Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Arginase Activity Protein Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Muscle Contraction Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Vasodilation Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Retrograde Trans-synaptic Signaling By Nitric Oxide Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Cardiac Conduction	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Arginine Catabolic Process Aging Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Arginine Catabolic Process To Ornithine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Negative Regulation Of T Cell Proliferation Response To Drug Defense Response To Protozoan Response To Amino Acid Neutrophil Degranulation Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Neutrophil Mediated Killing Of Fungus Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis	Neutrophil degranulation Urea cycle
Drugs		Citrulline Donepezil Ketamine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Formic acid 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide 1-hydroxy-2-isopropylguanidine N-omega-propyl-L-arginine 2-butyl-1-hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Flavin adenine dinucleotide Flavin mononucleotide N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Nicotinamide adenine dinucleotide phosphate S-Ethyl-N-Phenyl-Isothiourea [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium 5-N-Allyl-arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue	Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases			Hyperargininemia
GWAS		Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Type 2 diabetes ( 30054458)
Interacting Genes		33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23	6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Entrez ID		4842	383
HPRD ID		01226	01947
Ensembl ID		ENSG00000089250	ENSG00000118520
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	P05089
PDB IDs		4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC 6PNA 6PNB 6PNC 6PND 6PNE 6PNF 6PNG 6PNH 6PO5 6PO7 6PO8 6PO9 6POA 6POB 6POC 6POT	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F
Enriched GO Terms of Interacting Partners?
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