NINJ2 and EREG

Data Source:
BioGRID (two hybrid)

		NINJ2	EREG
Description		ninjurin 2	epiregulin
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Nervous System Development Tissue Regeneration	MAPK Cascade Angiogenesis Ovarian Cumulus Expansion Oocyte Maturation Positive Regulation Of Cytokine Production Female Meiotic Nuclear Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation MRNA Transcription Anatomical Structure Morphogenesis Animal Organ Morphogenesis Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Ovulation Positive Regulation Of Interleukin-6 Production ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Positive Regulation Of Phosphorylation Luteinizing Hormone Signaling Pathway Response To Peptide Hormone Keratinocyte Proliferation Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Primary Follicle Stage Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Membrane Organization Regulation Of Cell Motility
Pathways			Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Stroke ( 19369658) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)	Attention deficit hyperactivity disorder ( 18821565) Breast size ( 22747683) Metabolite levels ( 22916037)
Interacting Genes		74 interacting genes: AMIGO1 AQP6 ARL13B BCL2L13 BTNL9 CD69 CD79A CEACAM3 CHODL CLEC17A CLEC7A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ELOVL5 EREG ERGIC3 ERVFRD-1 EVI2B FAM209A FAM210B FCGRT FCRL4 FNDC9 GJA1 GPR152 GPR42 ICAM3 IFNGR1 IL3RA JAGN1 KCNJ6 KIR2DL3 KIR3DL3 LDLRAD1 LHFPL5 LMNA LYPD5 LYVE1 M6PR MGST3 MMGT1 MR1 MUC1 ODF4 PIGP PVR RIC3 RNASEK SCN3B SLAMF8 SLC10A1 SLC10A6 SLC66A1 SLC7A14 SLC7A8 STX1A STX2 TM4SF20 TMEM101 TMEM139 TMEM14B TMEM31 TMEM51 TMEM52B TMEM86B TMEM9 TMPRSS2 TMX2 TSPAN12 VMA21 VSIG1	6 interacting genes: CXCL9 EGFR ERBB4 MS4A13 NINJ2 OLFM4
Entrez ID		4815	2069
HPRD ID		09530	03638
Ensembl ID		ENSG00000171840	ENSG00000124882
Uniprot IDs		A0A590UJR9 B4DJC1 F5H3L1 F8WBZ3 Q9NZG7	O14944
PDB IDs			1K36 1K37 5E8D 5WB7
Enriched GO Terms of Interacting Partners?
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