NGFR and ZNF274

Data Source:
HPRD (in vitro, in vivo)

		NGFR	ZNF274
Description		nerve growth factor receptor	zinc finger protein 274
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Integral Component Of Membrane Growth Cone Dendritic Spine Perikaryon	Nucleolus Cytoplasm
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cellular Glucose Homeostasis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Rho Protein Signal Transduction Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K9 Trimethylation
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Cholesterol, total ( 25961943) LDL cholesterol ( 25961943) Ovarian cancer ( 30557369)
Interacting Genes		48 interacting genes: ANXA7 BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	1 interacting genes: NGFR
Entrez ID		4804	10782
HPRD ID		01197	05682
Ensembl ID		ENSG00000064300	ENSG00000171606
Uniprot IDs		P08138	A0A0A0MR47 Q96GC6
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG
Enriched GO Terms of Interacting Partners?
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