NFYB and SMYD3

Data Source:
BioGRID (two hybrid)

		NFYB	SMYD3
Description		nuclear transcription factor Y subunit beta	SET and MYND domain containing 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Toenail selenium levels ( 25343990)	Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		26 interacting genes: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 ELF1 EP300 GRB2 MAOB MEOX2 MYC NFYA NFYC POLE4 POU3F2 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3	21 interacting genes: APP CAMK2B CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		4801	64754
HPRD ID		01794	12297
Ensembl ID		ENSG00000120837	ENSG00000185420
Uniprot IDs		A0A024RBG7 F8VSL3 P25208	B3KN46 Q9H7B4
PDB IDs		1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS	3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF
Enriched GO Terms of Interacting Partners?
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