NFIC and GLRX

Data Source:
HPRD (in vivo, in vitro)

		NFIC	GLRX
Description		nuclear factor I C	glutaredoxin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Nucleus Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Electron Transfer Activity Glutathione Disulfide Oxidoreductase Activity Protein N-terminus Binding Glutathione Oxidoreductase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Nucleobase-containing Small Molecule Interconversion Electron Transport Chain Positive Regulation Of Membrane Potential Protein Deglutathionylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Interconversion of nucleotide di- and triphosphates
Drugs			Glutathione
Diseases
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Metabolite levels ( 23823483) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		25 interacting genes: CBLC CREBBP DACH1 EPHA2 FBXO7 GLIS1 GLIS2 GLRX LATS2 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 RELA RFX1 SOX3 TEAD2 TH TKTL2 TLX1 TPD52L3 ZCCHC14 ZKSCAN7	8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62
Entrez ID		4782	2745
HPRD ID		09009	02707
Ensembl ID		ENSG00000141905	ENSG00000173221
Uniprot IDs		B7Z4T6 P08651	A0A024RAM2 P35754
PDB IDs			1B4Q 1JHB 4RQR
Enriched GO Terms of Interacting Partners?
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