ATP1A3 and ASH2L

Data Source:
BioGRID (enzymatic study)

		ATP1A3	ASH2L
Description		ATPase Na+/K+ transporting subunit alpha 3	ASH2 like, histone lysine methyltransferase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Integral Component Of Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	Amyloid-beta Binding P-type Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Metal Ion Binding Chaperone Binding Ion Antiporter Activity Involved In Regulation Of Presynaptic Membrane Potential Steroid Hormone Binding	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding
	Biological Process	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Regulation Of Cardiac Conduction Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Ouabain
Diseases		Primary torsion dystonia (PTD)
GWAS		Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)	Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)
Interacting Genes		2 interacting genes: ATXN1 CASP8	37 interacting genes: ACTC1 ACTN2 ANKRD1 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WDR5 WWP1 ZSCAN1
Entrez ID		478	9070
HPRD ID		01666	05309
Ensembl ID		ENSG00000105409	ENSG00000129691
Uniprot IDs		P13637 Q53ES0	B4DPT1 F5H8F7 Q9UBL3
PDB IDs			3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE
Enriched GO Terms of Interacting Partners?
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