ATOH1 and POLE2

Data Source:
HPRD (two hybrid)

		ATOH1	POLE2
Description		atonal bHLH transcription factor 1	DNA polymerase epsilon 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromatin DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Neuron Migration Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Notch Signaling Pathway Axon Guidance Central Nervous System Development Cerebral Cortex Development Neuron Differentiation Inner Ear Morphogenesis Auditory Receptor Cell Fate Specification Auditory Receptor Cell Fate Determination Negative Regulation Of Apoptotic Process Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis
Pathways			Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: HMGB1 HUWE1	19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620
Entrez ID		474	5427
HPRD ID		03270	16007
Ensembl ID		ENSG00000172238	ENSG00000100479
Uniprot IDs		Q92858	P56282
PDB IDs			2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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