DRG1 and CAPNS1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DRG1	CAPNS1
Description		developmentally regulated GTP binding protein 1	calpain small subunit 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Membrane Nuclear Body	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Transcription Factor Binding Potassium Ion Binding Identical Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Cytoplasmic Translation Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Microtubule Polymerization Regulation Of Mitotic Spindle Assembly	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Cornification
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			PD150606
Diseases
GWAS		Fish- and plant-related diet ( 32066663) Neutrophil count ( 32888494 27863252) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		16 interacting genes: CAPNS1 CLDN1 COIL LNX1 LYL1 MEOX2 PHC2 PTEN RWDD1 SKIL SRPK2 SSX2IP STK16 TAL1 UBE2I ZC3H15	20 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5
Entrez ID		4733	826
HPRD ID		16034	00240
Ensembl ID		ENSG00000185721	ENSG00000126247
Uniprot IDs		Q9Y295	A0A0C4DGQ5 P04632
PDB IDs		2EKI	1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?
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