SERPINC1 and PIGC

Data Source:
BioGRID (affinity chromatography technology)

		SERPINC1	PIGC
Description		serpin family C member 1	phosphatidylinositol glycan anchor biosynthesis class C
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding	Catalytic Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Response To Nutrient Lactation Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Blood Coagulation, Intrinsic Pathway	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs		Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases		Inherited thrombophilia
GWAS		Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)	Daytime sleep phenotypes ( 27126917) Hemoglobin levels ( 32327693) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		6 interacting genes: F2 KLK1 KLK2 KLK6 PLG SDC2	4 interacting genes: DPM2 KLF10 PIGQ ZHX1
Entrez ID		462	5279
HPRD ID		00122	03433
Ensembl ID		ENSG00000117601	ENSG00000135845
Uniprot IDs		A0A024R944 P01008	Q92535
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?
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