MYF5 and RARG

Data Source:
BioGRID (two hybrid)

		MYF5	RARG
Description		myogenic factor 5	retinoic acid receptor gamma
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cartilage Condensation Ossification Somitogenesis Regulation Of Cell-matrix Adhesion Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Skeletal Muscle Tissue Development Extracellular Matrix Organization Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Camera-type Eye Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Glandular Epithelial Cell Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Hormone-mediated Signaling Pathway Anterior/posterior Pattern Specification Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		Myogenesis Myogenesis	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R667 LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
Diseases
GWAS			Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cardiorespiratory fitness (800m run time) ( 32572135) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		34 interacting genes: ANKRD11 AQP1 C14orf119 CALM1 CALM2 CALM3 CCDC13 CHIC2 CSNK2A1 CSNK2A2 ENKD1 FAM124B FIGLA ID1 ID2 ID3 ITGB4 MDFI MSGN1 NHLH2 PACRGL PIN1 RARG SCX SGF29 SNAPC5 TCEANC TCF3 TLE5 ZNF250 ZNF417 ZNF575 ZNF587 ZNF835	33 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576
Entrez ID		4617	5916
HPRD ID		01168	01573
Ensembl ID		ENSG00000111049	ENSG00000172819
Uniprot IDs		P13349	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs			1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0
Enriched GO Terms of Interacting Partners?
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