MUC2 and GALNT12

Data Source:
HPRD (in vitro)

		MUC2	GALNT12
Description		mucin 2, oligomeric mucus/gel-forming	polypeptide N-acetylgalactosaminyltransferase 12
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Lumen Plasma Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Inner Mucus Layer Outer Mucus Layer	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway O-glycan Processing Maintenance Of Gastrointestinal Epithelium	O-glycan Processing Protein Phosphopantetheinylation
Pathways			Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Asthma ( 31361310 31959851 30929738 32296059) Asthma (adult onset) ( 30929738) Interstitial lung disease ( 23583980) Medication use (adrenergics, inhalants) ( 31015401)	Asthma ( 31959851) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		4 interacting genes: GALNT12 GALNT14 MLH1 PLEKHM1	16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC
Entrez ID		4583	79695
HPRD ID		11828	13561
Ensembl ID		ENSG00000198788	ENSG00000119514
Uniprot IDs			Q8IXK2
PDB IDs			6PXU
Enriched GO Terms of Interacting Partners?
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