MTX1 and TOMM40

Data Source:
BioGRID (pull down)

		MTX1	TOMM40
Description		metaxin 1	translocase of outer mitochondrial membrane 40
Image		No pdb structure
GO Annotations	Cellular Component	SAM Complex Cytoplasm Integral Component Of Membrane MIB Complex	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Pore Complex
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Porin Activity
	Biological Process	Mitochondrion Organization Inner Mitochondrial Membrane Organization Lactation Protein Transport	Protein Targeting To Mitochondrion Macroautophagy Protein Import Into Mitochondrial Matrix
Pathways		Mitochondrial protein import Cristae formation	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462 31451708) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866) General risk tolerance (MTAG) ( 30643258) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Red blood cell count ( 32888494 27863252) Renal function-related traits (BUN) ( 22797727) Serum cancer antigen 15.3 levels ( 31666285) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urea levels ( 28270201)	Age-related macular degeneration ( 22694956 23326517) Alzheimer's disease ( 22832961 24770881 30636644 18823527 19734902 29107063 24755620 19125160 20061627) Alzheimer's disease (age of onset) ( 29107063 22005931) Alzheimer's disease (late onset) ( 20885792 23565137 26339675) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 30319691 28641921 29274321 20932310) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30319691 28641921) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 19060911) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870 23207651) Cognitive decline (age-related) ( 28078323 24468470) Cognitive function ( 25644384) Cognitive impairment test score ( 30319691) Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) HDL cholesterol ( 21909109 19060911) Hippocampal atrophy rate ( 31760383) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lamb consumption ( 32066663) LDL cholesterol ( 26160806 19060911) LDL cholesterol levels ( 26763881) Lipid traits ( 24386095) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Quantitative traits ( 19197348) Refractive error ( 32231278) Sense of smell ( 26632684) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglycerides ( 19060911) Type 2 diabetes ( 27189021 30297969) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)
Interacting Genes		3 interacting genes: CLN8 MTX2 TOMM40	8 interacting genes: HSD17B10 HSP90AA1 HSPA4 MTX1 PRKN SAMM50 TOMM20 TOMM7
Entrez ID		4580	10452
HPRD ID		11861	16274
Ensembl ID		ENSG00000173171	ENSG00000130204
Uniprot IDs		Q13505	O96008
PDB IDs			7CK6
Enriched GO Terms of Interacting Partners?
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