MTNR1B and CDH4

Data Source:
BioGRID (two hybrid)

		MTNR1B	CDH4
Description		melatonin receptor 1B	cadherin 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse	Plasma Membrane Integral Component Of Plasma Membrane Catenin Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity	Calcium Ion Binding Cadherin Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Negative Regulation Of CGMP-mediated Signaling Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Neuronal Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Adherens Junction Organization Positive Regulation Of Axon Extension Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Adherens junctions interactions Myogenesis Myogenesis
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases		Type II diabetes mellitus
GWAS		Acute insulin response ( 28490609) Adverse response to radiation therapy ( 23719583) Birth weight ( 31043758 27680694) Chronotype ( 30696823) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Depressive symptoms x dependent stressful life events interaction (1df test) ( 30718454) Depressive symptoms x dependent stressful life events interaction (2df test) ( 30718454) Diabetes (gestational) ( 22233651) Fasting blood glucose ( 29844224 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907 19060909 19651812 22508271) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 20858683 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Hemoglobin A1c levels ( 29403010) High fasting blood glucose ( 31910446) Homeostasis model assessment of beta-cell function ( 20081858) Incremental insulin ( 24699409) Insomnia (caffeine-induced) ( 22754043) Insulin disposition index ( 24699409 28490609) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758 29309628) Peak insulin response ( 28490609) Pulse pressure ( 30224653 30578418) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 28254843 32499647 20581827 28869590) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) 3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Axial length ( 24144296) Cerebrospinal T-tau levels ( 20932310) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Fish intake frequency ( 31320941) General cognitive ability ( 29844566) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Longevity ( 20834067) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Sudden cardiac arrest ( 21658281) Volumetric brain MRI ( 17903297)
Interacting Genes		133 interacting genes: ACKR1 ACTN1 ADCY3 ANXA6 AP1B1 AP4E1 APOL6 ARHGAP1 ARHGAP28 ATP6V0B BCL2L1 BCL2L13 BTBD1 CANX CD99 CDC16 CDH11 CDH13 CDH4 CLASP1 CLDND1 COG4 COG8 COPA COX11 CRELD1 CSE1L CTNNA1 CTNND1 CUL3 DISP3 DMXL2 DST DYNC1H1 DYNC2H1 EBF1 EBP EIF3A ERG28 ESPL1 EVA1A FANCI FLNA FSTL1 FTL GGT7 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB4 GPM6B GPR50 HARS1 HECTD1 HNRNPA0 HSPA5 INTS1 IPO4 IPO9 IRF2BP2 IRS4 ITM2C ITPR3 KMT2C LTBR MACF1 MARCHF6 MARF1 MFF MIA3 MMP2 MON2 MTMR6 MTNR1A OTX1 PCDHB10 PCNX4 PDIA3 PDIA6 PEAK1 PI4KA PIDD1 POLI PPM1G PPP1R21 PPP6R1 PRKDC PSMD8 PSME3IP1 PTPRD RECK RIPOR2 RNF185 RNF40 RNF41 RPRD2 SDHD SF3A3 SLC12A4 SLC2A3 SLC30A1 SLC39A6 SLC3A2 SLC4A7 SMARCD1 SMC3 SREBF1 SREBF2 STMN4 SYNE2 TANGO6 TBCD THOC1 THRA TINF2 TLN1 TMEM14A TMEM230 TRIM24 TRIM46 TRIP12 UBAP2L UBQLN2 UBQLN4 UBR4 USP34 VPS35 XBP1 YWHAB YWHAQ	3 interacting genes: CDH2 MTNR1B UBE2I
Entrez ID		4544	1002
HPRD ID		02882	04304
Ensembl ID		ENSG00000134640	ENSG00000179242
Uniprot IDs		P49286	P55283
PDB IDs		6ME6 6ME7 6ME8 6ME9
Enriched GO Terms of Interacting Partners?
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