GGNBP1 and EIF2AK4

Data Source:
BioGRID (two hybrid)

		GGNBP1	EIF2AK4
Description		gametogenetin binding protein 1 (pseudogene)	eukaryotic translation initiation factor 2 alpha kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Membrane	Cytosol Polysome Cytosolic Ribosome
	Molecular Function		TRNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Mitochondrial Fission Multicellular Organism Development Spermatogenesis Cell Differentiation	DNA Damage Checkpoint Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Adaptive Immune Response Regulation Of Translational Initiation Protein Phosphorylation Cell Cycle Arrest Learning Long-term Memory Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Viral Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of CREB Transcription Factor Activity Cellular Response To Amino Acid Starvation Cellular Response To UV EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress Induction By Virus Of Host Autophagy Negative Regulation By Host Of Viral Genome Replication Negative Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Protein Autophosphorylation Defense Response To Virus Regulation Of Feeding Behavior Cellular Response To Cold Positive Regulation Of Translational Initiation In Response To Starvation GCN2-mediated Signaling Positive Regulation Of Long-term Synaptic Potentiation Neuron Projection Extension Cellular Response To Leucine Starvation
Pathways			Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Mean platelet volume ( 32888494) Multiple sclerosis and systolic blood pressure (pleiotropy) ( 26920376) Platelet count ( 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252)	Body mass index ( 24827717) Corneal curvature ( 22969067) Diastolic blood pressure ( 27841878) Ewing sarcoma ( 22327514) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Response to haloperidol in psychosis ( 24751813) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		2 interacting genes: EIF2AK4 GGN	4 interacting genes: GGNBP1 SMAD1 SMAD4 TGFBR1
Entrez ID		449520	440275
HPRD ID		13575	18447
Ensembl ID		ENSG00000204188	ENSG00000128829
Uniprot IDs			Q9P2K8
PDB IDs			6N3L 6N3N 6N3O
Enriched GO Terms of Interacting Partners?
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