ASPH and DEFB1

Data Source:
BioGRID (two hybrid)

		ASPH	DEFB1
Description		aspartate beta-hydroxylase	defensin beta 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane	Extracellular Region Extracellular Space Golgi Lumen Extrinsic Component Of Membrane Extracellular Exosome Sperm Midpiece Microvesicle
	Molecular Function	Peptide-aspartate Beta-dioxygenase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	Protein Binding CCR6 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Muscle Contraction Protein Phosphopantetheinylation Electron Transport Chain Ion Transmembrane Transport Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cardiac Conduction	Innate Immune Response In Mucosa Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Response To Bacterium Antimicrobial Humoral Response Antibacterial Humoral Response CAMP-mediated Signaling Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Stimuli-sensing channels Ion homeostasis	Beta defensins Defensins
Drugs		Aspartic acid
Diseases
GWAS		Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)	Blood pressure ( 24954895) Blood protein levels ( 30072576 29875488) Dental caries (decayed and filled deciduous teeth) ( 31533690) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Plasma kynurenine levels in major depressive disorder ( 29317604) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Psoriatic arthritis ( 26626624)
Interacting Genes		71 interacting genes: AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LRPAP1 LTA NUCB2 OCIAD1 PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11A SMIM11B SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	6 interacting genes: ASPH CCR6 HAP1 MAP4K2 RIF1 VIM
Entrez ID		444	1672
HPRD ID		08996	03634
Ensembl ID		ENSG00000198363	ENSG00000164825
Uniprot IDs		B4DQ07 B7ZM96 Q12797	P60022
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9	1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
Enriched GO Terms of Interacting Partners?
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