H3-5 and SETMAR

Data Source:
BioGRID (two hybrid)

		H3-5	SETMAR
Description		H3.5 histone	SET domain and mariner transposase fusion gene
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GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus	Condensed Chromosome Nucleus Nucleolus Site Of Double-strand Break
	Molecular Function	Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Protein Homodimerization Activity DNA Topoisomerase Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Positive Regulation Of Cell Growth	DNA Double-strand Break Processing DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Via Nonhomologous End Joining Cell Population Proliferation Histone H3-K36 Methylation DNA Integration Replication Fork Processing Mitotic DNA Integrity Checkpoint Histone H3-K4 Methylation Negative Regulation Of Cell Cycle Arrest Nucleic Acid Phosphodiester Bond Hydrolysis Histone H3-K36 Dimethylation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization
Pathways
Drugs
Diseases
GWAS			Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1	1 interacting genes: H3-5
Entrez ID		440093	6419
HPRD ID		18443	10225
Ensembl ID		ENSG00000188375	ENSG00000170364
Uniprot IDs		Q6NXT2	B4DND2 Q53H47 Q96H41
PDB IDs		2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3	3BO5 3F2K 3K9J 3K9K
Enriched GO Terms of Interacting Partners?
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