MPO and CP

Data Source:
HPRD (in vitro)

		MPO	CP
Description		myeloperoxidase	ceruloplasmin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Lysosome Secretory Granule Azurophil Granule Lumen Azurophil Granule Intracellular Membrane-bounded Organelle Extracellular Exosome Phagocytic Vesicle Lumen	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Chromatin Binding Peroxidase Activity Protein Binding Heparin Binding Heme Binding Metal Ion Binding	Ferroxidase Activity Copper Ion Binding Oxidoreductase Activity Chaperone Binding
	Biological Process	Response To Yeast Hypochlorous Acid Biosynthetic Process Respiratory Burst Involved In Defense Response Defense Response Response To Oxidative Stress Aging Response To Mechanical Stimulus Removal Of Superoxide Radicals Response To Food Response To Lipopolysaccharide Low-density Lipoprotein Particle Remodeling Defense Response To Bacterium Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Cell Redox Homeostasis Defense Response To Fungus Response To Gold Nanoparticle	Copper Ion Transport Iron Ion Transport Cellular Iron Ion Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis
Pathways		Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport
Drugs		Mesalazine Cefdinir Levocarnitine Melatonin Nomifensine	Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Circulating myeloperoxidase levels (plasma) ( 23620142) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Subcutaneous adipose tissue ( 22589738)
Interacting Genes		1 interacting genes: CP	7 interacting genes: ATP7A BTRC GAST LTF MPO PLG PROC
Entrez ID		4353	1356
HPRD ID		06102	00317
Ensembl ID		ENSG00000005381	ENSG00000047457
Uniprot IDs		P05164	A5PL27 P00450
PDB IDs		1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX 5FIW 5MFA 5UZU 6AZP 6BMT	1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?
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