MPL and PTPRF

Data Source:
BioGRID (proximity labelling technology)

		MPL	PTPRF
Description		MPL proto-oncogene, thrombopoietin receptor	protein tyrosine phosphatase receptor type F
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Thrombopoietin Receptor Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding
Pathways		Platelet Aggregation (Plug Formation)	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs		Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases		Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ	59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B VCAN ZNF512B
Entrez ID		4352	5792
HPRD ID		01161	01552
Ensembl ID		ENSG00000117400	ENSG00000142949
Uniprot IDs		P40238	G1UI20 P10586
PDB IDs			1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW
Enriched GO Terms of Interacting Partners?
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