KITLG and UBE2V1

Data Source:
HPRD (in vitro)

		KITLG	UBE2V1
Description		KIT ligand	ubiquitin conjugating enzyme E2 V1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding
	Biological Process	MAPK Cascade Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	Activation Of MAPK Activity Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated JNK Cascade Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination
Pathways			NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Familial progressive hyperpigmentation
GWAS		Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1	47 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN PSMD14 RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1
Entrez ID		4254	7335
HPRD ID		01698	04294
Ensembl ID		ENSG00000049130	ENSG00000244687
Uniprot IDs		A0A024RBC0 A0A024RBF5 P21583	G3V2F7 Q13404
PDB IDs		1EXZ 1SCF 2E9W	2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?
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