MEN1 and MYH9

Data Source:
HPRD (in vivo, in vitro)

		MEN1	MYH9
Description		menin 1	myosin heavy chain 9
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Brush Border Adherens Junction Focal Adhesion COP9 Signalosome Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Myosin II Complex Cell Leading Edge Neuromuscular Junction Cleavage Furrow Protein-containing Complex Actomyosin Extracellular Exosome Myosin II Filament
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein-macromolecule Adaptor Activity Protein N-terminus Binding R-SMAD Binding	Microfilament Motor Activity RNA Binding Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Protein Domain Specific Binding Actin-dependent ATPase Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Histone Lysine Methylation Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Telomerase Activity Beta-catenin-TCF Complex Assembly	Meiotic Spindle Organization Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Lysosome Localization Cytokinetic Process Uropod Organization Blood Vessel Endothelial Cell Migration Regulated Exocytosis Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair
Pathways		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis
Drugs			Artenimol
Diseases		Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma	Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome
GWAS		Urate levels ( 21768215)	Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic nerve measurement (rim area) ( 20395239) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM	25 interacting genes: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 GRB2 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM UBE2I YWHAZ
Entrez ID		4221	4627
HPRD ID		00564	01177
Ensembl ID		ENSG00000133895	ENSG00000100345
Uniprot IDs		A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5	A0A024R1N1 P35579
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6WNH	2LNK 3ZWH 4CFQ 4CFR 4ETO
Enriched GO Terms of Interacting Partners?
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