MEF2A and PHB2

Data Source:
HPRD (in vivo)

		MEF2A	PHB2
Description		myocyte enhancer factor 2A	prohibitin 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Mitochondrial Prohibitin Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Mitochondrial Genome Maintenance Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Apoptotic Process Heart Development Muscle Organ Development Positive Regulation Of Cardiac Muscle Hypertrophy Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion	Activation Of MAPK Activity Mitophagy Immunoglobulin Production Protein Import Into Nucleus Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Sister Chromatid Cohesion Activation Of Phospholipase C Activity Response To Wounding Cell Migration CD40 Signaling Pathway Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Induction By Virus Of Host Autophagy RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity Activation Of Protein Kinase C Activity
Pathways		ERK/MAPK targets Myogenesis	Processing of SMDT1
Drugs			Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cervical cancer ( 28806749) Dental caries (decayed and filled deciduous teeth) ( 31533690) Gestational age at birth (maternal effect) ( 28598419) Systolic blood pressure ( 30224653 30578418)	Glycated hemoglobin levels ( 28898252) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		29 interacting genes: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 DNMT3L EP300 ERBIN HAND1 HDAC4 HDAC5 HDAC7 HDAC9 HSF2BP MAPK14 MAPK7 MEF2D MEOX1 MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4	21 interacting genes: AFP AKT1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PRKCA PTEN PTMA RNF2 TEAD3 UPF2
Entrez ID		4205	11331
HPRD ID		02807	17843
Ensembl ID		ENSG00000068305	ENSG00000215021
Uniprot IDs		A0A0S2Z417 A0A0S2Z453 A0A0S2Z454 A0A0S2Z4C8 A0A0S2Z4N0 A8K720 Q02078	Q99623
PDB IDs		1C7U 1EGW 1LEW 3KOV 3MU6 3P57 6BYY 6BZ1	6IQE
Enriched GO Terms of Interacting Partners?
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