MCM2 and MCM10

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MCM2	MCM10
Description		minichromosome maintenance complex component 2	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm MCM Complex CMG Complex	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex
	Molecular Function	DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation Negative Regulation Of DNA Helicase Activity	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)	Nicotine dependence symptom count ( 25555482)
Interacting Genes		57 interacting genes: AKAP8 APP ASF1A ATM ATR CCNB2 CCNC CDC45 CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CDT1 CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GINS4 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP	38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		4171	55388
HPRD ID		00303	11297
Ensembl ID		ENSG00000073111	ENSG00000065328
Uniprot IDs		P49736	Q7L590
PDB IDs		4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7
Enriched GO Terms of Interacting Partners?
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