MARK1 and USH2A

Data Source:
BioGRID (affinity chromatography technology)

		MARK1	USH2A
Description		microtubule affinity regulating kinase 1	usherin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Basement Membrane Cytoplasm Integral Component Of Membrane Apical Plasma Membrane Photoreceptor Connecting Cilium Stereocilium Bundle Ciliary Basal Body Neuronal Cell Body Terminal Bouton Stereocilium Membrane Periciliary Membrane Compartment USH2 Complex
	Molecular Function	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Collagen Binding Myosin Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization	Visual Perception Sensory Perception Of Sound Animal Organ Morphogenesis Tissue Development Cell Migration Substrate Adhesion-dependent Cell Spreading Hair Cell Differentiation Establishment Of Protein Localization Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Response To Stimulus Sensory Perception Of Light Stimulus Inner Ear Receptor Cell Differentiation
Pathways
Drugs		Fostamatinib
Diseases			Usher syndrome (US) Retinitis pigmentosa (RP)
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Birth weight ( 31043758) Cholesterol ( 31902109) Chronic mucus hypersecretion ( 25234806) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Prepulse inhibition of the startle response ( 31596458)
Interacting Genes		10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2	3 interacting genes: BRCA1 COL4A3 KRT18
Entrez ID		4139	7399
HPRD ID		07353	09759
Ensembl ID		ENSG00000116141	ENSG00000042781
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	O75445
PDB IDs		2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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