MAOA and NDRG1

Data Source:
HPRD (in vivo)

		MAOA	NDRG1
Description		monoamine oxidase A	N-myc downstream regulated 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Integral Component Of Membrane	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Primary Amine Oxidase Activity	Protein Binding Microtubule Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Cellular Biogenic Amine Metabolic Process Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Neurotransmitter Metabolic Process Neurotransmitter Catabolic Process Dopamine Catabolic Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Regulation Of Apoptotic Process Mast Cell Activation Cellular Response To Hypoxia Postsynapse Organization
Pathways		Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Norepinephrine Neurotransmitter Release Cycle Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolism of serotonin Defective MAOA causes Brunner syndrome (BRUNS) Interleukin-4 and Interleukin-13 signaling	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Amphetamine Phentermine Procaine Tranylcypromine Phenelzine Minaprine Zonisamide Selegiline Procarbazine Moclobemide Moclobemide Isocarboxazid Ephedra sinica root MMDA 4-Methoxyamphetamine Metamfetamine Pargyline Flavin adenine dinucleotide Clorgiline Nialamide Nomifensine Zimelidine Posizolid CX157 Decyl(dimethyl)phosphine oxide Harmine Pirlindole Toloxatone Brofaromine Flortaucipir F-18
Diseases		Brunner syndrome; MAOA deficiency	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Smoking behavior ( 19247474)	Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		1 interacting genes: NDRG1	70 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		4128	10397
HPRD ID		02400	05586
Ensembl ID		ENSG00000189221	ENSG00000104419
Uniprot IDs		P21397 Q49A63 Q53YE7	B3KWB2 Q8N959 Q92597
PDB IDs		1H8Q 2BXR 2BXS 2Z5X 2Z5Y
Enriched GO Terms of Interacting Partners?
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