MAN2C1 and EXOSC6

Data Source:
BioGRID (two hybrid)

		MAN2C1	EXOSC6
Description		mannosidase alpha class 2C member 1	exosome component 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	Alpha-mannosidase Activity Carbohydrate Binding Metal Ion Binding	RNA Binding Exoribonuclease Activity
	Biological Process	Mannose Metabolic Process Oligosaccharide Catabolic Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Lysosomal oligosaccharide catabolism	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		5 interacting genes: BRCA1 EXOSC6 NLGN3 PRRC2A XRN1	37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		4123	118460
HPRD ID		01109	12107
Ensembl ID		ENSG00000140400	ENSG00000223496
Uniprot IDs		A0A140VJN9 Q9NTJ4	Q5RKV6
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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