SMAD4 and NOTCH4

  • Data Source:
  • HPRD (in vivo, in vitro)

SMAD4

NOTCH4

Description SMAD family member 4 notch receptor 4
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Advanced glycation end-product levels ( 26083729)
  • Age-related macular degeneration ( 22694956)
  • Aspartate aminotransferase levels ( 29403010)
  • Asthma ( 21804548 31619474)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Bipolar disorder ( 31043756)
  • Blood protein levels ( 28240269)
  • Blood protein levels in cardiovascular risk ( 28369058)
  • Chronic hepatitis B infection ( 25802187)
  • Circulating myeloperoxidase levels (serum) ( 23620142)
  • Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947)
  • Colorectal cancer ( 30529582)
  • Crohn's disease ( 23266558)
  • Epstein-Barr virus immune response (EBNA-1) ( 23326239)
  • Food antigen IgG levels ( 24962563)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • High light scatter reticulocyte count ( 32888494)
  • HIV-1 control ( 20041166)
  • Inflammatory bowel disease ( 28067908)
  • Iron status biomarkers (iron levels) ( 28334935)
  • Joint mobility (Beighton score) ( 27182965)
  • Longevity ( 30294719)
  • Lung cancer ( 28604730)
  • Lung cancer in ever smokers ( 28604730)
  • Lupus nephritis in systemic lupus erythematosus ( 24925725)
  • Migraine ( 27322543)
  • Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430)
  • Obesity-related traits ( 23251661)
  • Objective response to lithium treatment in bipolar disorder ( 26503763)
  • Prostate cancer ( 23535732)
  • Reticulocyte count ( 32888494)
  • Reticulocyte fraction of red cells ( 27863252)
  • Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)
  • Schizophrenia ( 19571808 30285260 23894747)
  • Squamous cell lung carcinoma ( 28604730)
  • Systemic lupus erythematosus ( 21408207)
  • Systemic sclerosis ( 21779181)
  • Takayasu arteritis ( 25604533)
  • Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
  • Ulcerative colitis ( 24837172 28067908)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes 214 interacting genes: ACVR1B AKT1 ALDOB AOPEP AP2B1 APBB2 AR ARFRP1 ARL5B ATF2 ATF7IP BAAT BCAS3 BEX1 BRCA1 BTRC CAMK2G CCDC180 CD59 CDC14B CEBPA CEBPB CEBPD CHEK1 CITED1 CNKSR1 COPS5 CREBBP CSH1 CSH2 CTCF CTNNB1 CYFIP2 DACH1 DCP1A DCP1B DKK3 DLX1 DNAJB2 DNMT3L DVL1 ECSIT EEF1A1 EID2 EIF2AK4 EP300 ERBIN ESR1 ESR2 ETV4 EWSR1 FANCC FBLN1 FBP2 FBXO30 FBXO34 FHL2 FHL3 FN1 FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 FSTL3 GATA2 GLI3 GPNMB GREB1 HDGF HDLBP HEMGN HMG20A HNF4A HOXA9 HOXC8 HRAS HYAL2 IL24 ITK JUN JUNB JUND LAMTOR5 LEF1 LMO4 LRATD2 LYPD3 MAPK1 MAPK13 MAX MDM4 MECOM MEF2A MEX3B MSANTD3 MYOD1 NAT8 NEK6 NELFCD NFIA NFKBID NKX3-2 NOTCH4 NR0B2 NRAS NUAK2 NUP214 OTUB1 PAK1 PAPPA2 PARD3 PBK PIAS1 PIAS2 PIAS3 PIAS4 PLG PLK4 PPP2CB PPP3R2 PRKAR1B PRKAR2A PRPF40A PSG2 PSG9 PSMD11 RAB13 RAB25 RAB2B RAB34 RAB38 RAB3B RAC2 RALA RASD2 RASL12 RASSF5 RBL1 RELA RFX1 RHEBL1 RHOD RHOG RHOJ RIPK2 RMND5B RPL28 RPS27A RRAS2 RSPH14 S100A14 SASH3 SERPINA1 SERPINB5 SFRP2 SFRP4 SHC1 SKI SKIL SKP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD7 SMAD9 SNIP1 SNRNP70 SNW1 SOX12 SP1 SPTBN1 SQSTM1 STK11IP STK35 STUB1 STX17 TCTA TDG TENM3 TFE3 TGFBR1 TGFBR2 TGFBRAP1 THRSP TIAF1 TLE5 TM9SF2 TOB1 TRAP1 TSSK3 TSTD2 UBA52 UBB UBE2I UBE2L3 UBE2Z UHRF2 USB1 USP10 USP4 USP9X WWOX XPO5 ZBED5 ZBTB7A ZIC1 ZMYM2 ZNF189 ZNF423 ZNF510 ZNF521 ZNF8 13 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4
Entrez ID 4089 4855
HPRD ID 02995 01290
Ensembl ID ENSG00000141646 ENSG00000204301
Uniprot IDs A0A024R274 Q13485 A0A1U9X983 Q99466
PDB IDs 1DD1 1G88 1MR1 1U7F 1U7V 1YGS 5C4V 5MEY 5MEZ 5MF0 5UWU
Enriched GO Terms of Interacting Partners?
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