LYN and IL1B

Data Source:
BioGRID (pull down)

		LYN	IL1B
Description		LYN proto-oncogene, Src family tyrosine kinase	interleukin 1 beta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Extracellular Region Extracellular Space Lysosome Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Ion Channel Binding Ephrin Receptor Binding Phosphoprotein Binding Phosphorylation-dependent Protein Binding	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding
	Biological Process	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Cell Differentiation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Gap Junction Assembly Positive Regulation Of T-helper 1 Cell Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs		Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib	Donepezil Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Foreskin keratinocyte (neonatal) Binimetinib Gevokizumab Dilmapimod
Diseases
GWAS		Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 32888494 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)
Interacting Genes		125 interacting genes: ACTB ADAM15 AR BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB2 ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119	15 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1
Entrez ID		4067	3553
HPRD ID		01301	00985
Ensembl ID		ENSG00000254087	ENSG00000125538
Uniprot IDs		A8K379 P07948 Q6NUK7	P01584
PDB IDs		1W1F 1WA7 3A4O 5XY1 6NMW	1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 5R7W 5R85 5R86 5R87 5R88 5R89 5R8A 5R8B 5R8C 5R8D 5R8E 5R8F 5R8G 5R8H 5R8I 5R8J 5R8K 5R8L 5R8M 5R8N 5R8O 5R8P 5R8Q 6I1B 6Y8I 6Y8M 7I1B 9ILB
Enriched GO Terms of Interacting Partners?
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